منابع مشابه
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A.
Gene mutations involving epigenetic regulators recently have been described in adult acute myeloid leukemia (AML). Similar studies are limited in children. We analyzed gene mutations and cooperation in pediatric AML with special reference on mutated epigenetic regulators. Nineteen gene mutations, including 8 class I genes, 4 class II genes, WT1 and TP53 (class III), and 5 epigenetic regulator g...
متن کاملFLT3 mutations in childhood acute lymphoblastic leukemia.
Activating mutations of the FLT3 receptor tyrosine kinase are common in acute myelogenous leukemia (AML) but are rare in adult acute lymphoblastic leukemia (ALL). We have recently shown that FLT3 is highly expressed and often mutated in ALLs with rearrangement of the mixed lineage leukemia (MLL) gene on chromosome 11q23. Because hyperdiploid ALL samples also show high-level expression of FLT3, ...
متن کاملF.A.B.CLASSIFICATION OF CHILDHOOD LEUKEMIA IN IRAN
Bone marrow specimens from leukemic patients were studied in a 5 year period beginning in 1982 in Children's Medical Center of Teheran,a teaching and referral center for pediatric medicine. The slides were stained by Giemsa-Wright stains, read by at least two persons experienced in bone marrow pathology and classified according to F.A.B. recommendations. Peroxidase or Sudan black-B and P.A...
متن کاملNumber and type of TET2 mutations in chronic myelomonocytic leukemia and their clinical relevance
TET2, located on chromosome 4q24, is frequently mutated (~60%) in patients with chronic myelomonocytic leukemia (CMML). TET2 has 11 exons, and variations, especially in exon 3 have been described as a part of age-related clonal hematopoiesis. In a large population-based study (n= 17 182), somatic variations involving DNMT3A, TET2 and ASXL1 were seen in ~ 11% of the population 480 years of age, ...
متن کاملPrognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia
Mutations involving epigenetic regulators (TET2~60% and ASXL1~40%) and splicing components (SRSF2~50%) are frequent in chronic myelomonocytic leukemia (CMML). On a 27-gene targeted capture panel performed on 175 CMML patients (66% males, median age 70 years), common mutations included: TET2 46%, ASXL1 47%, SRSF2 45% and SETBP1 19%. A total of 172 (98%) patients had at least one mutation, 21 (12...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2010
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2010.243